Groupe Synthèse Organique et Biostructures


Page personnelle de Manh Thong Cung
Directeur de Recherches CNRS


1, rue Grandville - B.P. 451 - 54001 Nancy France
Tél +33 (0)3 83 17 51 07 - Fax +33 (0)3 83 37 99 77
Manh-Thong.Cung@ensic.inpl-nancy.fr

 

Activités

  • Analyse structurale de peptides et analogues bioactifs (RMN et modélisation moléculaire)
  • Structure de ligands au contact de protéines: applications aux systèmes anticorps-antigène (maladies auto-immunes, vaccins…) et aux systèmes du type enzyme-inhibiteur, enzyme-cofacteur

  • Etude structurale de protéines (RMN 3D triple résonance)

Collaborations scientifiques

  •   Institut de Biologie Moléculaire et Cellulaire, UPR 9021 CNRS, Strasbourg (Muller S et Briand J-P)
  •   Laboratoire de Chimie Organique et Biochimie d'Ioannina, Grèce (Sakarellos C)
  •   Institut Pasteur Hellénique d'Athènes, Grèce (Tzartos SJ et Soteriadou KP)
  •   Laboratoire 'Maturation des ARN et Enzymologie Moléculaire, UMR 7567 CNRS-UHP, Nancy (Branlant C et Branlant G)


Sociétés savantes

  • American Peptide Society,
  • European Peptide Society,
  • Groupe Français des Peptides,
  • Société Française de Biophysique

Publications récentes

  • Solution structure of a retro-inverso peptide analogue mimicking the foot-and-mouth disease virus major antigen site: Structural basis for its antigenic crossreactivity with the parent peptide
    PETIT MC, BENKIRANE N, GUICHARD G, PHAN-CHAN-DU A, MARRAUD M, CUNG MT, BRIAND JP, MULLER S
    Journal of Biological Chemistry 274 (1999) 3686-3692

  • Engineered glycolytic glyceraldehyde-3-phosphate dehydrogenase binds the anti-conformation of NAD+ nicotinamide but does not experience a specific hydride transfer
    EYSCHEN J, VITOUX B, MARRAUD M, CUNG MT, BRANLANT G
    Archives of Biochemistry and Biophysics (364 (1999) 219-227

  • Solvent dependent conformational properties of the main immunogenic region of the acetylcholine receptor in myasthenia gravis
    Tsikaris V, Sakarellos-Daitsiotis M, Orlewski P, Cung MT, Marraud M, Tzartos SJ, Sakarellos C
    Bioactive Peptides in Drug Discovery and Design: Medical Aspects (Matsoukas J, Mavromoustakos T, Eds) IOS Press (1999) 203-212

  • The 3D-structure of the complex between an Fv antibody fragment and an analogue of the main immunogenic region of the acetylcholine receptor: A combined 2D-NMR, homology and molecular modeling approaches
    KLEINJUNG J, PETIT MC, ORLEWSKI P, MAMALAKI A, TZARTOS SJ, TSIKARIS V, SAKARELLOS-DAITSIOTIS M, SAKARELLOS C, MARRAUD M, CUNG MT
    Biopolymers 53, 113-128 (2000)

  • The position of the LysNeH2- grafted antigens along the sequential oligopeptide carrier, Ac-(Aib-Lys-Aib-Gly)n (SOCn -II), influences the antibody recognition: application to the Sm main autoimmune epitope. ALEXOPOULOS C, TSIKARIS V, RIZOU C, SAKARELLOS-DAITSIOTIS M, SAKARELLOS C, MARRAUD M, CUNG MT, VLACHOYIANNOPOULOS PG, MOUTSOPOULOS HM Biopolymers, 54, 1-10 (2000)
  • Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear overhauser effect spectroscopy and molecular dynamics approach PHAN-CHAN-DU A, PETIT MC, GUICHARD G, BRIAND JP, MULLER S AND CUNG MT Biochemistry, 40, 5720-5727 (2001).
  • Structure of epitopes recognized by the antibodies to alpha(181-192) peptides of neuronal nicotinic acetylcholine receptors: extrapolation to the structure of acetylcholine-binding domain. SKOK M, LYKHMUS E, BOBROVNIK S, TZARTOS S, TSOULOUFIS T, VANDERESSE R, COUTROT F, CUNG MT, MARRAUD M, KRIKORIAN D AND SAKARELLOS-DAITSIOTIS M J. Neuroimmunol., 121, 59-66 (2001)
 

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